Pregnancy and multiple sclerosis: 2022 recommendations from the French multiple sclerosis society.

  • Sandra Vukusic
  • Clarisse Carra-Dalliere
  • Jonathan Ciron
  • Elisabeth Maillart
  • Laure Michel
  • Emmanuelle Leray
  • Anne-Marie Guennoc
  • Bertrand Bourre
  • David Laplaud
  • Géraldine Androdias
  • Caroline Bensa
  • Kevin Bigaut
  • Damien Biotti
  • Pierre Branger
  • Olivier Casez
  • Mikael Cohen
  • Elodie Daval
  • Romain Deschamps
  • Cécile Donze
  • Anne-Laure Dubessy
  • Cécile Dulau
  • Françoise Durand-Dubief
  • Maxime Guillaume
  • Benjamin Hebant
  • Laurent Kremer
  • Arnaud Kwiatkowski
  • Julien Lannoy
  • Adil Maarouf
  • Eric Manchon
  • Guillaume Mathey
  • Xavier Moisset
  • Alexis Montcuquet
  • Julie Pique
  • Thomas Roux
  • Romain Marignier
  • Christine Lebrun-Frenay

Source: Mult Scler

Publié le


OBJECTIVE: The objective of this study was to develop evidence-based recommendations on pregnancy management for persons with multiple sclerosis (MS).

BACKGROUND: MS typically affects young women in their childbearing years. Increasing evidence is available to inform questions raised by MS patients and health professionals about pregnancy issues.

METHODS: The French Group for Recommendations in Multiple Sclerosis (France4MS) reviewed PubMed and university databases (January 1975 through June 2021). The RAND/UCLA appropriateness method was developed to synthesise the scientific literature and expert opinions on healthcare topics; it was used to reach a formal agreement. Fifty-six MS experts worked on the full-text review and initial wording of recommendations. A group of 62 multidisciplinary healthcare specialists validated the final proposal of summarised evidence.

RESULTS: A strong agreement was reached for all 104 proposed recommendations. They cover diverse topics, such as pregnancy planning, follow-up during pregnancy and postpartum, delivery routes, locoregional analgesia or anaesthesia, prevention of postpartum relapses, breastfeeding, vaccinations, reproductive assistance, management of relapses and disease-modifying treatments.

CONCLUSION: The 2022 recommendations of the French MS society should be helpful to harmonise counselling and treatment practice for pregnancy in persons with MS, allowing for better and individualised choices.